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Van der Woude syndrome may cause a cleft lip and/or palate or an isolated cleft palate. It can also cause pits in the lower lip and this is usually the clue to the person having the syndrome. This syndrome is also variable in how it affects people who may only have pits in the lip that they are not really aware of, or they may have lip pits and a very severe cleft lip and/or palate.  The syndome is inherited in an autosomal dominant way, meaning that if a person has Van der Woude syndrome they will have a 50% chance of passing the condition on to their children.