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This syndrome is the result of a deletion on the long arm of chromosome 22.  It is also known as DiGeorge syndrome, Shpritzen syndrome and Velocardiofacial syndrome. It can cause a very large number of anomalies including charachteristic facial features, cardiac anomolies, palate problems, low blood calcium levels and low immunity. People with this syndrome may have many or only some of the possible problems and each of these to a varying degree. So, for example, the palatal problems may be an isolated cleft palate, a submoucous cleft palate, or a soft palate that looks normal but does not function normally causing problems with speech and sometimes feeding, or no palate problems at all.